Dynamics of EBV and the Potential for Vaccinations in the United States

Submitting Student(s)

Lucas Dupuy
Liv Cantrell

Session Title

Poster Session 1

Faculty Mentor

Kristen Abernathy, Ph.D.

College

College of Arts and Sciences

Department

Mathematics

Abstract

Epstein-Barr virus (EBV) is one of the most common human viruses, with roughly 90% of the population in the United States carrying the virus by adulthood. EBV is spread through bodily fluids and infections tend to be asymptomatic, however in some cases EBV can lead to infectious mononucleosis (IM) and some cancers such as Hodgkin’s lymphoma. Currently there is no approved vaccine, but clinical trials are in development. This study presents a mathematical model of EBV transmission, calibrated using data from the United States, to compare possible vaccine strategies with varying efficacies, duration, and age of vaccination.

Previously Presented/Performed?

SAEOPP McNair/SSS Scholars Research Conference, Buckhead, GA, June 2022 | Winthrop University Showcase of Winthrop University Undergraduate Research and Creative Endeavors, Rock Hill, SC, April 2023

Type of Presentation

Poster presentation

Grant Support?

Supported by an SC-INBRE grant from the National Institute for General Medical Sciences (P20GM103499).

Start Date

15-4-2023 12:00 PM

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Apr 15th, 12:00 PM

Dynamics of EBV and the Potential for Vaccinations in the United States

Epstein-Barr virus (EBV) is one of the most common human viruses, with roughly 90% of the population in the United States carrying the virus by adulthood. EBV is spread through bodily fluids and infections tend to be asymptomatic, however in some cases EBV can lead to infectious mononucleosis (IM) and some cancers such as Hodgkin’s lymphoma. Currently there is no approved vaccine, but clinical trials are in development. This study presents a mathematical model of EBV transmission, calibrated using data from the United States, to compare possible vaccine strategies with varying efficacies, duration, and age of vaccination.