Event Title

Investigating Semaphorin 3A as a Possible Repulsive Axon Guidance Molecule in the Chick Visual System.

Poster Number

052

Faculty Mentor

Eric Birgbauer, Ph.D.

College

College of Arts and Sciences

Department

Department of Biology

Location

Richardson Ballroom (DIGS)

Start Date

20-4-2018 2:15 PM

End Date

20-4-2018 4:15 PM

Description

During the development of the visual system, retinal ganglion cells (RGCs) must project their axons to the synaptic targets in the brain. A variety of different molecules, known as axon guidance cues, play an important role in this process. At the end of each axon there is a growth cone, a finger-like projection that detects these molecules in the environment and reacts to them. Some axon guidance cues are repulsive and cause a growth cone collapse and retraction. One such axon guidance molecule is semaphorin 3A (Sema3A), which has been shown to cause dorsal root ganglion cells (DRG) to undergo growth cone collapse in vitro. In the visual system, previous studies indicate that Sema3A leads to RGC growth cone collapse in mouse and Xenopus, but not in chick. We have analyzed this species difference and, contrary to previous literature, we have found that Sema3A treatment leads to a dose-dependent growth cone collapse of retinal axons as well as DRGs in embryonic chick. Therefore, Sema3A might play an important role during the development of the visual system.

Previously Presented/Performed?

Fourth Annual Showcase of Undergraduate Research and Creative Endeavors (SOURCE), Winthrop University, April 2018

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Apr 20th, 2:15 PM Apr 20th, 4:15 PM

Investigating Semaphorin 3A as a Possible Repulsive Axon Guidance Molecule in the Chick Visual System.

Richardson Ballroom (DIGS)

During the development of the visual system, retinal ganglion cells (RGCs) must project their axons to the synaptic targets in the brain. A variety of different molecules, known as axon guidance cues, play an important role in this process. At the end of each axon there is a growth cone, a finger-like projection that detects these molecules in the environment and reacts to them. Some axon guidance cues are repulsive and cause a growth cone collapse and retraction. One such axon guidance molecule is semaphorin 3A (Sema3A), which has been shown to cause dorsal root ganglion cells (DRG) to undergo growth cone collapse in vitro. In the visual system, previous studies indicate that Sema3A leads to RGC growth cone collapse in mouse and Xenopus, but not in chick. We have analyzed this species difference and, contrary to previous literature, we have found that Sema3A treatment leads to a dose-dependent growth cone collapse of retinal axons as well as DRGs in embryonic chick. Therefore, Sema3A might play an important role during the development of the visual system.