Title of Abstract

Neurodegenerative Pathways Involved in Age Related and Sensorineural Hearing Loss: A Review

Session Title

Biological Science Research

Faculty Mentor

LaShardai Brown, Ph.D.; brownl@winthrop.edu

College

College of Arts and Sciences

Department

Biology

Faculty Mentor

LaShardai Brown, Ph.D.

Abstract

Hearing loss is one of the most common diseases associated with aging, both in the United States and across the world.Sensorineural hearing loss (SNHL) occurs due to damage of the inner cochlear organs or cochlear nerve, whereas age related hearing loss (ARHL), also known as presbycusis, is a neurodegenerative result of aging. Several cellular changes occur in both forms including hair cell loss, death of spiral ganglion neurons (SGNs) as well as changes to the lateral wall.Cochlear implants are often used to treat symptoms of both type of hearing loss. However, hearing aids are only effective when a certain percentage of cells are still active. Therefore, newer therapies focus on inhibiting inflammatory pathways and the prevention of degeneration due to the molecular pathways associated with hearing loss. The NFkB pathway and complement pathway play a critical role in age related and neurodegenerative diseases, exacerbating and driving cellular death of auditory cells and thus provide insight into a common disease with no currently known cure. A synthetic reading of current literature suggests the role of these signaling networks in hearing loss and the advancement of inflammation and cellular degeneration, as it relates to ARHL.

Additional Fields About Your Abstract

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Honors Thesis Committee

LaShardai Brown, Ph.D ; Michael Lipscomb, Ph.D; Daniel Stovall, Ph.D; Courtney Guenther, Ph. D.

Honors Thesis Committee

LaShardai Brown, Ph.D ; Michael Lipscomb, Ph.D; Daniel Stovall, Ph.D; Courtney Guenther, Ph. D.

Course Assignment

HONR 450H - Brown & HONR 451H - Lipscomb

Start Date

16-4-2021 12:45 PM

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Apr 16th, 12:45 PM

Neurodegenerative Pathways Involved in Age Related and Sensorineural Hearing Loss: A Review

Hearing loss is one of the most common diseases associated with aging, both in the United States and across the world.Sensorineural hearing loss (SNHL) occurs due to damage of the inner cochlear organs or cochlear nerve, whereas age related hearing loss (ARHL), also known as presbycusis, is a neurodegenerative result of aging. Several cellular changes occur in both forms including hair cell loss, death of spiral ganglion neurons (SGNs) as well as changes to the lateral wall.Cochlear implants are often used to treat symptoms of both type of hearing loss. However, hearing aids are only effective when a certain percentage of cells are still active. Therefore, newer therapies focus on inhibiting inflammatory pathways and the prevention of degeneration due to the molecular pathways associated with hearing loss. The NFkB pathway and complement pathway play a critical role in age related and neurodegenerative diseases, exacerbating and driving cellular death of auditory cells and thus provide insight into a common disease with no currently known cure. A synthetic reading of current literature suggests the role of these signaling networks in hearing loss and the advancement of inflammation and cellular degeneration, as it relates to ARHL.