Title of Abstract

Optimal control of an HIV model with gene therapy and latency reversing agents

Faculty Mentor

Two WU mentors: Zach Abernathy, Ph.D.; Kristen Abernathy, Ph.D.; abernathyz@winthrop.edu; abernathyk@winthrop.edu

College

College of Arts and Sciences

Department

Mathematics

Faculty Mentor

Zach Abernathy, Ph.D.; Kristen Abernathy, Ph.D.

Abstract

In this project, we study the dynamics of HIV under gene therapy and latency reversing agents. For constant treatment controls, we establish global stability of the disease-free equilibrium and endemic equilibrium based on the value of the basic reproductive ratio. We then consider time dependent controls and formulate an associated optimal control problem that emphasizes reduction of the latent reservoir. Characterizations for the optimal control profiles are found using Pontryagin's Maximum Principle. We perform numerical simulations of the optimal control model using the fourth-order Runge-Kutta forward-backward sweep method. We conclude with findings that suggest a combination treatment of gene therapy with latency reversing agents provides better remission times than gene therapy alone.

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Grant Support

This project was supported by SC INBRE grants from the National Institute of General Medical Sciences (2P20 GM10349915) of the National Institutes of Health.

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Optimal control of an HIV model with gene therapy and latency reversing agents

In this project, we study the dynamics of HIV under gene therapy and latency reversing agents. For constant treatment controls, we establish global stability of the disease-free equilibrium and endemic equilibrium based on the value of the basic reproductive ratio. We then consider time dependent controls and formulate an associated optimal control problem that emphasizes reduction of the latent reservoir. Characterizations for the optimal control profiles are found using Pontryagin's Maximum Principle. We perform numerical simulations of the optimal control model using the fourth-order Runge-Kutta forward-backward sweep method. We conclude with findings that suggest a combination treatment of gene therapy with latency reversing agents provides better remission times than gene therapy alone.